Persephone was like a welcoming gift to him. She saw beyond Hades' impetuous figure and saw someone honest and fair. Although she is very nice, Zagreus says that it is not a good idea to irritate her because it is implied that she inherited the powers of her mother and can be as destructive as when she is angry. She is very warm, affectionate, and advises Zagreus, and it is decided that she will return exclusively to him. She is also skilled at persuading others to achieve her objectives, leveraging her charisma and previous position as the queen of the Underworld to convince the inflexible Charon to give her a ride to her destination, a trait that Zagreus visibly inherited from her. Persephone is resourceful and adept at adapting to new situations, she has a 'green thumb', which explains how she was able to establish herself in an uninhabited area and quickly cultivate various types of vegetables there. She is a good leader and could extract the best from everyone, making the dark Underworld a more productive and inviting place. Persephone is very affable, but without losing her prestige, considered reliable and respectable, treating everyone as equals, praising House members for their good work. She is considered decent company by Nyx, loved by everyone in the Underworld, and they miss her very much. She values sincerity and could not bear the constant fights, lies, and betrayals of the Olympians, which led her to hide and move to the Underworld. Persephone grew up with an excessively controlling and manipulative mother who did not let her walk on her own feet and take her own actions, so this was enough for her to crave freedom and become curious and develop an interest in knowing and living new things. She seems to exhibit many qualities such as her good humor, loving nature, resilience, fairness, sociability, and great courage, leaving her reign as Queen behind and her dwelling in the magnificent Mount Olympus forever.

Persephone is the goddess of harvest, daughter of Demeter, wife of Hades, and biological mother of Zagreus. On the other hand, Hades is unsympathetic to Zagreus' attempts to pry more information about his mother, although he does mention that she always despised the name Kore. Demeter seems to pay no heed to rumors surrounding her daughter's disappearance, even doubting her brother Helios when he told her that Persephone journeyed to the Underworld. She left Olympus at some point in the past, and Demeter attempted to search for her in vain. She reveals that Persephone's father was an ordinary mortal and a farmer, and that she called her Kore, although she later took on the name Persephone. One of them, anyway.' Demeter will also confide in Zagreus regarding her daughter.

In one conversation, Thanatos mentions that Zagreus has 'her (green) eyes. Little is known regarding Persephone's appearance, until Zagreus reaches Greece.

The Olympian gods are, however, still unaware of this fact at the story's start, and do not know Zagreus' true motives in escaping the Underworld.

Before the events of the game, nobody in the House except for Nyx and Hades themselves knew that Persephone was Zagreus' mother by the start of the game, everyone in the House (sans Hypnos) has learned that this is the case. She is known only from a flashback sequence triggered by Zagreus sleeping in his room, and from conversations between Zagreus and Nyx. Following her departure, Hades forbade all mentions of her in the House, and as such she remains a figure of mystery. Had she died, she would have returned to the House as he does via the River Styx. It is unknown why she left, or if she was successful in her escape, but she did not die. She is Zagreus' birth mother, but has since left for the world above. She married Hades and was noted to be a stately, kind woman as the Queen of the Underworld. Persephone is the goddess of vegetation (particularly grain), and a daughter of Demeter.

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